Hepatoprotective activity of Chhit-Chan-Than extract powder against carbon tetrachlorideinduced liver injury in rats

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Hepatoprotective activity of Chhit-Chan-Than extract powder against carbon tetrachlorideinduced liver injury in rats

Yi-Chun Lin [et al.] - Nama Orang;

The capability of Chhit-Chan-Than extract powder (CCTEP, 10% aqueous Ocimum gratissimum L. extract) to protect against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity in vivo was investigated. Wistar rats were divided into five groups. Group A was a normal control group given only vehicle; Group B, the hepatotoxic group, was
injected intraperitoneally twice a week with repeated 8% CCl4/olive oil (0.1 mL/100 g of body weight); Groups CeE, extract-treated groups received CCl4 and different doses of CCTEP (100 mg/kg and 200 mg/kg) or silymarin (200 mg/kg of body weight) daily by gavage for 8 weeks, respectively. The results showed that the CCl4-induced histopathogical
changes may be prevented by CCTEP through reducing the intercellular collogen stack,dropping blood serum alanine aminotransferase and aspartate aminotransferase levels,and restoring the catalase activity and glutathione content. The hepatoprotective properties were further confirmed by the marked improvement in histopathological examination and by quantitative steatosis-fibrosis scoring. The above results suggest that CCTEP is able to prevent the liver inflammation and fibrosis induced by repeated CCl4 administration,and the hepatoprotective effects might be correlated partly with its antioxidant and free radical scavenging effects.

Keywords:
Antioxidants Carbon tetrachloride Hepatoprotection

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Judul Seri: j o u rnal of food and drug a n a l y s i s
No. Panggil: -
Penerbit: : Elsevier Taiwan., 2014
Deskripsi Fisik: j o u rnal of food and drug a n a l y s i s 2 2 ( 2 0 1 4 ) 2 2 0 e2 2 9
Bahasa: English
ISBN/ISSN: -
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: Food And Health
Info Detail Spesifik: -
Pernyataan Tanggungjawab: Wati/Agus

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FULL TEXT:Hepatoprotective activity of Chhit-Chan-Than extract powder against carbon tetrachlorideinduced liver injury in rats

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