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Electrochemical oxidation behavior of hydrochlorothiazide on a glassy carbon electrode and its voltammetric determination in pharmaceutical formulations and biological fluids

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The electrochemical oxidation behavior of hydrochlorothiazide (HCT) on a glassy carbon as a working electrode was investigated in BrittoneRobinson (BeR) buffer pH 3, by using anodic stripping voltammetry (ASV) and cyclic voltammetry (CV). This drug gave a welldefined voltammetric oxidation peak at þ 1200 mV versus an Ag/AgCl reference electrode.
The electrochemical oxidation process was shown to be irreversible and diffusion controlled, with adsorption characterized over the entire pH range. The optimized conditions,such as accumulation time and potential, scan rate, frequency, pulse amplitude, varying of working electrodes, and instrumental parameters were studied. The calibration
graph for HCT was obtained from 4  10e6 to 4  10e5 M (correlation coefficient ¼ 0.997)using the developed electroanalytical method (ASV). The detection limit of this drug was 4.3  10e9 M. ASV and CV techniques with adequate precision and accuracy have been developed and applied for direct determination of HCT in commercial tablets without
separation or extraction procedures and biological fluids such as urine and plasma.

Keywords:
Anodic stripping voltammetry Cyclic voltammetry Electro-oxidation Glassy carbon Hydrochlorothiazide

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Informasi Detail

Judul Seri

j ournal of food and drug anal ys i s

No. Panggil

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Penerbit

: Elsevier Taiwan., 2014

Deskripsi Fisik

j ournal of food and drug anal ys i s 2 2 ( 2 0 1 4 ) 3 6 3 e3 6 9

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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