e-journal
Autophagy in drug-induced liver toxicity
Liver injury resulting from exposure to drugs and chemicals is a major health problem.Autophagy is an important factor in a wide range of diseases, such as cancer, liver disease,muscular disorder, neurodegeneration, pathogen infection, and aging, and emerging evidence indicates that autophagy makes a substantial contribution to the pathogenesis of
drug- and chemical-induced liver toxicity. In this review, we summarize current knowledge on autophagy triggered by toxicants/toxins, the protective role of autophagy in liver toxicity, and the underlying molecular mechanisms. We also highlight experimental approaches for studying autophagy.
Keywords:
autophagy drug-induced liver toxicity
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