e-journal

Development of standardized methodology for identifying toxins in clinical samples and fish species associated with tetrodotoxin-borne poisoning incidents

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Tetrodotoxin (TTX) is a naturally occurring toxin in food, especially in puffer fish. TTX poisoning is observed frequently in South East Asian regions. In TTX-derived food poisoning outbreaks, the amount of TTX recovered from suspicious fish samples or leftovers,and residual levels from biological fluids of victims are typically trace. However,liquid chromatographyemass spectrometry and liquid chromatographyetandem mass spectrometry methods have been demonstrated to qualitatively and quantitatively determine TTX in clinical samples from victims. Identification and validation of the TTXoriginating seafood species responsible for a food poisoning incident is needed. A polymerase
chain reaction-based method on mitochondrial DNA analysis is useful for identification of fish species. This review aims to collect pertinent information available on TTXborne food poisoning incidents with a special emphasis on the analytical methods employed for TTX detection in clinical laboratories as well as for the identification of TTXbearing
species.

Keywords:
identification liquid chromatographyetandem mass spectrometry polymerase chain reaction method coupled with restriction fragment length polymorphism tetrodotoxin tetrodotoxin poisoning incident

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Ketersediaan

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Informasi Detail

Judul Seri

j o u r n a l of food and drug a n a l y s i s

No. Panggil

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Penerbit

: Elsevier Taiwan., 2016

Deskripsi Fisik

j o u r n a l of food and drug a n a l y s i s 2 4 ( 2 0 1 6 ) 9e1 4

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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