e-journal

In vitro modulation of TH1 and TH2 cytokine expression by edible tuber ofDioscorea alata and study of correlation patterns of the cytokine expression

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The underground tuber of Dioscorea alata is a palatable food and is also claimed to have therapeutic effects. Various groups of researchersdemonstrated different activities of this tuber such as antioxidant, hepatoprotective, anti-ulcer and anti-diabetic activities. Therefore, the aim of thepresent study was to evaluate the immunomodulatory potentialities of 70% hydro-methanolic extract of D. alata underground tubers by investigatingdifferent parameters like the expression of interferon gamma (IFN-), interleukin (IL)-2, IL-4 and IL-10, in addition to its effect on the proliferationof murine splenic T-lymphocytes in vitro. Results demonstrated that D. alata can actively polarize the TH0 lymphocyte population towards theexpression of TH1 immune response by up-regulating the IFN- and IL-2 expression and down-regulating the IL-4 and IL-10 expression. The tuberextract also proved to possess mitogenic activity as evidenced by the proliferation of lymphocytes in vitro.

Keywords: Anti-inflammatory; Cytokine; Dioscorea (yam); Immunomodulation; Lymphocyte; MTT; Proliferation

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2014

Deskripsi Fisik

Food Science and Human Wellness 3 (2014) 1–8

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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