e-journal

A comparative study on antioxidant potentials, inhibitory activities againstkey enzymes related to metabolic syndrome, and anti-inflammatory activityof leaf extract from different Momordica species

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Momordica species are vegetable crops widely distributed in warmer regions of the world. In this work, we describe the antioxidant, enzymeinhibitory and anti-inflammatory effects of the leaves from three different species of Momordica. The present investigation was initially carried out toexplore the possible link between antioxidant, enzyme inhibitory property of Momordica leaf extract and their total phenolic and flavonoid contents.The anti-inflammatory activity was tested by using carrageenan-induced paw edema. Our results illustrated an enhanced antioxidant power of wildspecies comparable with a commercial variety. In addition, the leaf extract of M. dioica (200 mg/kg) presented a significant anti-inflammatoryactivity toward carrageenan-induced paw edema in Wistar rats in comparison to indomethacin (10 mg/kg). The contents of flavonoids and totalphenolic compounds could be correlated with the antioxidant and enzymes inhibition activities. The major bioactive compounds of phenolic acidsand flavonoids such as gallic acid, chlorogenic acid, caffeic acid, ferulic acid, ellagic acid, catechin, rutin, and quercetin were identified. Ourfindings suggest that wild Momordica species contains higher potential antioxidant and anti-inflammatory activities than a commercial varietydoes, which could be tested as drug candidates against oxidative and inflammation-related pathological processes.

Keywords: Momordica; Antioxidant; In vitro antidiabetic; Cholinesterase; Anti-inflammatory

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Ketersediaan

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2014

Deskripsi Fisik

Food Science and Human Wellness 3 (2014) 36–46

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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