e-journal

Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maximaagainst paracetamol induced liver injury in rats

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The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolicleaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was inducedby paracetamol (2 g/kg) on day 5. Silymarin (100 mg/kg body weight) was used as reference standard. On the 7th day animals were sacrificed andliver function markers (ALT, AST, ALP), total bilirubin and total protein in blood serums and hepatic antioxidants (SOD, CAT, GSH and GPx) inliver homogenate were estimated. The leaf extracts restored the liver function markers and hepatic antioxidants to the normal level than elevatedlevels noticed on paracetamol control at P < 0.001. Reversal of hepatoarchitecture has also been registered. The present study shows that C. hystrixand C. maxima leaf extracts possess hepatoprotective action against paracetamol induced hepatotoxicity.

Keywords: Citrus hystrix; Citrus maxima; Paracetamol; Silymarin; Hepatoprotection

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Ketersediaan

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2015

Deskripsi Fisik

Food Science and Human Wellness 4 (2015) 35–41

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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