e-journal

Carvacrol attenuates N-nitrosodiethylamine induced liver injury inexperimental Wistar rats

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Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari, which hasbeen assessed for substantial pharmacological properties. In recent years, notable research has been embarked on to establish the biological actionsof Carvacrol for its promising use in clinical applications. The present study is an attempt to reveal the protective role of Carvacrol against N-Nitrosodiethylamine (DEN) induced hepatic injury in male Wistar albino rats. DEN is an egregious toxin, present in numerous environmental factors,which enhances chemical driven liver damage by inducing oxidative stress and cellular injury. Administration of DEN (200 mg/kg bodyweight,I.P) to rats results in elevated marker enzymes (in both serum and tissue). Carvacrol (15 mg/kg body weight) suppressed the elevation of markerenzymes (in both serum and tissue) and augmented the antioxidants levels. The hoisted activities of Phase I enzymes and inferior activities of PhaseII enzymes were observed in DEN-administered animals, whereas Carvacrol treated animals showed improved near normal activity. Histologicalobservations also support the protective role of Carvacrol against DEN induced liver damage. Final outcome from our findings intimate thatCarvacrol might be beneficial in attenuating toxin induced liver damage.

Keywords: Carvacrol; DEN; Antioxidants; Hepatotoxicity; Liver damage; Marker enzyme

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2015

Deskripsi Fisik

Food Science and Human Wellness 4 (2015) 66–74

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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