e-journal

Ethylacetate extract of red onion (Allium cepa L.) tunic affectshemodynamic parameters in rats

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The effects of ethylacetate extract of red onion (Allium cepa) tunic (ACTE) on some hemodynamic and biochemical parameters were evaluatedin normotensive albino rats. Blood pressure parameters were determined in anaesthetized rats orally administered ACTE (10-, 20-, or 40 mg/kg)or ramipril (1 mg/kg) once daily for 14 days. Respectively, 10-, 20-, or 40 mg/kg ACTE produced significant (P < 0.01), dose-dependent fall insystolic blood pressure, SBP (21%, 27%, 33%), diastolic blood pressure, DBP (6%, 10%, 16%), pulse pressure, PP (42%, 49%, 56%), mean arterialblood pressure, MAPB (13%, 18%, 23%) and heart rate, HR (4%, 5%, 7%). The highest effective dose (40 mg/kg) compared well with ramipril(1 mg/kg) with regards to SBP (41%), DBP (19%), PP (70%), MABP (29%) and HR (10%). Similar trends (decreases) were recorded for 40 mg/kgACTE and ramipril, respectively, as regards the activities of serum enzymes: creatine kinase (60% and 65%), ALT (18% and 14%) and ALP (28%and 16%). HPLC fingerprints of the flavonoid-rich ACTE revealed that flavonols: quercetin, quercitrin, isoquercitrin, rutin and kaempferol are theactive flavonoids. The results demonstrate the hypotensive effect of A. cepa tunic flavonoids initiating further investigation of their individual orsynergistic contribution(s) to the observed effects.

Keywords: Allium cepa; Extract; Flavonoids; Hemodynamic; Hypotension

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2015

Deskripsi Fisik

Food Science and Human Wellness 4 (2015) 115–122

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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