e-journal

Methanol extracts of Brachystegia eurycoma and Detarium microcarpumseeds flours inhibit some key enzymes linked to the pathology andcomplications of type 2 diabetes in vitro

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The inhibitory effect of methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours on some key enzymes [-amylase,-glucosidase and aldose reductase (AR)] linked to the pathology and complications of type 2 diabetes (T2D); and their antioxidant properties wereevaluated. The antioxidant properties evaluated were DPPH•and ABTS•+scavenging abilities, reducing power, and antioxidant phytochemicals(total phenolics, tannins, total flavonoids and total saponins). Extracts of both flours inhibited -amylase, -glucosidase and AR in a dose-dependentmanner. The half-maximal inhibitory concentrations (IC50) of B. eurycoma on -amylase, -glucosidase, AR and lipid peroxidation were lower thanthose of D. microcarpum, indicating that it had stronger inhibitory potency than D. microcarpum. B. eurycoma also had significantly (P < 0.05)higher DPPH•and ABTS•+scavenging abilities, and reducing power than D. microcarpum. The antioxidant phytochemicals (total phenolics,tannins, total flavonoids and total saponins) were also significantly (P < 0.05) higher in B. eurycoma than D. microcarpum. The inhibitory effectof B. eurycoma and D. microcarpum extracts on -amylase, -glucosidase and AR activities may be attributed to the combined action of theirpolyphenols and total saponins, and this may be a possible mechanism of action providing support for their use in managing hyperglycemia andthe complications of T2D.

Keywords: Type 2 diabetes; Enzyme inhibition; Antioxidants; Phytochemical; Brachystegia eurycoma; Detarium microcarpum

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Informasi Detail

Judul Seri

Food Science and Human Wellness

No. Panggil

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Penerbit

: Elsevier B.V.., 2015

Deskripsi Fisik

Food Science and Human Wellness 4 (2015) 162–168

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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