Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidaseand Fe2+-induced lipid peroxidation in the kidney, liver, and lungs tissuesof rats in vitro

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Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidaseand Fe2+-induced lipid peroxidation in the kidney, liver, and lungs tissuesof rats in vitro

Emmanuel Anyachukwu Irondi [et al.] - Nama Orang;

The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase (XO) and Fe2+-induced lipidperoxidation in the kidney, liver and lungs tissues of rats were evaluated in vitro. Phenolics (flavonoids and phenolic acids) were quantifiedusing reverse-phase high performance liquid chromatrography coupled with diode array detection (HPLC-DAD). The XO and Fe2+-induced lipidperoxidation inhibitory abilities of the extract were evaluated using spectrophotometric methods. The extract contained some flavonoids andphenolic acids, including catechin, epicatechin, rutin, quercetin, luteolin, apigenin; gallic, chlorogenic, caffeic and ellagic acids that are beneficialto health. The extract inhibited XO in the kidney, liver and lungs tissues in a dose-dependent manner. The half-maximal inhibitory concentrations(IC50) of the extract on XO from the tissues varied significantly (P < 0.05), and were in the order of liver > kidney > lungs. The extract also inhibitedFe2+-induced lipid peroxidation in a dose-dependent pattern, having IC50in the order of liver > lungs > kidney. T. tetraptera fruit extract could bea promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions, due to its ability to inhibit XO; thisbioactivity is attributable to combined effect of its flavonoids and phenolic acids.

Keywords: Tetrapleura tetraptera; Phenolics; Xanthine oxidase; Hyperuricaemia; Lipid peroxidation

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Judul Seri: Food Science and Human Wellness
No. Panggil: -
Penerbit: : Elsevier B.V.., 2016
Deskripsi Fisik: Food Science and Human Wellness 5 (2016) 17–23
Bahasa: English
ISBN/ISSN: -
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: Food And Health
Info Detail Spesifik: -
Pernyataan Tanggungjawab: Wati/Agus

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FULL TEXT:Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidaseand Fe2+-induced lipid peroxidation in the kidney, liver, and lungs tissuesof rats in vitro

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