e-journal

Antiobesity effects of kimchi in diet-induced obese mice

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Background: The present study was investigated to confirm the antiobesity effect of kimchi in high-fat
diet-induced obese C57BL/6 mice.
Methods: Mice in the high-fat diet (HFD) group, standardized kimchi (S-Kimchi) group, and Korean
commercial kimchi (D-Kimchi) group, but not in the normal-diet group, were fed a high-fat diet (HFD) for
the first 4 weeks to induce obesity. From the 5th to 8th weeks, the S- and D-Kimchi groups were fed an
HFD containing 10% of S-Kimchi or D-Kimchi, respectively. After 8 weeks, mice were sacrificed and
obesity-related factors were determined.
Results: Body and adipose tissue weights were significantly lower in the kimchi-treated groups than in
the HFD group. In particular, in the D-Kimchi group, serum levels of triglyceride, total cholesterol, lowdensity
lipoprotein-cholesterol, insulin, and leptin were significantly lower, and serum levels of highdensity
lipoprotein-cholesterol and adiponectin were markedly higher than those in the HFD group.
Moreover, hepatic mRNA expression of adipogenesis-related genes (CCAAT/enhance-binding protein-a,
peroxisome proliferator-activated receptor-g, sterol regulatory element-binding protein-1c, and fatty
acid synthase) in the kimchi-treated groups were lower than those in the HFD group, but fatty acid
oxidation-related carnitine palmitoyltransferase-1 expressions were higher. In addition, kimchi
decreased the mRNA levels of the inflammation-related monocyte chemotactic protein-1 and
interleukin-6 in epididymal fat tissue.
Conclusion: Administration of kimchi, especially of D-Kimchi, which contained Leuconostoc mesenteroides
DRC 0211 starter and other subingredients, exhibited antiobesity activity by reducing body weight gains
and adipose tissue weights; modulating serum lipid profiles and hepatic lipogenesis; regulating serum
insulin, leptin, and adiponectin levels; and reducing adipocyte size and inflammatory response in
epididymal fat tissues.

Keywords:
antiobesity C57BL/6 mice high-fat diet kimchi obesity-related genes

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Ketersediaan

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Informasi Detail

Judul Seri

J Ethn Foods

No. Panggil

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Penerbit

: Elsevier., 2015

Deskripsi Fisik

J Ethn Foods 2 (2015) 137e144

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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