e-journal

Implications of oxidative damage to proteins and DNA in aging and its intervention by caloric restriction and exercise

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In this short review we describe implications of age-related changes of protein and DNA oxidation as a public mechanism of biological aging.Oxidativelymodified protein andDNAhave been demonstrated to increasewith advancing age in rodents. Half-life of proteins is extended andDNArepair activity declines in old animals.Dietary restriction initiated late in life can shorten the half-life of proteins to levels of young animals, thus contributing to reduce level of altered proteins in old animals by the regimen. Regular exercise reduced oxidativelymodified proteins in the brainwith improved cognitive functions. It attenuated oxidative stress in the liver, i.e., ameliorating activation of nuclear factor kB, increasing reduced glutathione, and decreasing oxidized guanine base in nuclear and mitochondrial DNA. These findings suggest that regular exercise has systemic effects in reducing oxidative stress. Thus, life-styles such as diet and exercisemay extend health span, by up-regulating overall anti-oxidant capacities that include proteins involved inprotein turnover and DNA repair, resulting in reduction of damaged proteins and DNA that potentially promote physiological and pathological aging.

Keywords: Aging; Dietary restriction; DNA; Exercise; Oxidative stress; Protein

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Ketersediaan

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Informasi Detail

Judul Seri

Journal of Sport and Health Science

No. Panggil

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Penerbit

: Shanghai University of Sport., 2013

Deskripsi Fisik

Journal of Sport and Health Science 2 (2013) 75e80

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Sport And Kesehatan

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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