e-journal

Role of PGC-1a in muscle function and aging

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This article focuses on the current underlying of molecular mechanisms of the peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1a) mediated pathway and discuss possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and ameliorating aging and aging-related diseases. PGC-1a is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors and mitochondrial transcription factor A, leading to increased mitochondrial DNA
replication and gene transcription. PGC-1a also regulates cellular oxidant-antioxidant homeostasis by stimulating the gene expression of superoxide dismutase-2, catalase, glutathione peroxidase 1, and uncoupling protein. Recent reports from muscle-specific PGC-1a overexpression underline the benefit of PGC-1a in muscle atrophy and sarcopenia, during which PGC-1a enhanced mitochondrial biogenic pathway and reduced oxidative damage. Thus, PGC-1a seems to have a protective role against aging associated skeletal muscle deterioration.

Keywords: Aging; Mitochondria; Muscle; PGC-1a; Signaling

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Informasi Detail

Judul Seri

Journal of Sport and Health Science

No. Panggil

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Penerbit

: Shanghai University of Sport., 2013

Deskripsi Fisik

Journal of Sport and Health Science 2 (2013) 81e86

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Sport And Kesehatan

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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