e-journal

Mitochondrial redox metabolism in aging: Effect of exercise interventions

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Mitochondrial redox metabolism has long been recognized as being central to the effects of aging and the development of age-related pathologies in the major oxidative organs. Consistent evidence has shown that exercise is able to retard the onset and impede the progression of aging by modifying mitochondrial oxidanteantioxidant homeostasis. Here we provide a broad overview of the research evidence showing the relationship between mitochondrial redox metabolism, aging and exercise. We address part aspects of mitochondrial reactive oxygen species (ROS) metabolism, from superoxide production to ROS detoxification, especially antioxidant enzymes and uncoupling protein. Furthermore, we describe mitochondrial remodeling response to aging and exercise, which is accompanied by bioenergetics and redox regulation. In addition,potential mechanisms for redox signaling involved in mitochondrial remodeling and redox metabolism regulation are also reviewed.

Keywords: Aging; Exercise; Mitochondrial remodeling; PGC-1a; Reactive oxygen species

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Ketersediaan

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Informasi Detail

Judul Seri

Journal of Sport and Health Science

No. Panggil

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Penerbit

: Shanghai University of Sport., 2013

Deskripsi Fisik

Journal of Sport and Health Science 2 (2013) 67e74

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Sport And Kesehatan

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

Lampiran Berkas

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