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Cefazolin-containing poly(ε-caprolactone) sponge pad to reduce pin tract infection rate in rabbits

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In our previous study, a fibroblast growth factor-2 (FGF-2)eapatite composite layer coated on titanium screws effectively prevented pin tract infection in rabbits because of enhanced wound healing; however, the FGF-2eapatite composite layers did not completely prevent pin tract infection. Thus, we recently developed a poly(ε-caprolactone) (PCL) sponge pad embedded with cefazolin sodium (þCEZ), which has a fastacting bactericidal effect. The pad is placed on the skin around the screws. The purpose of this study was to determine the anti-infective efficacy
of the þCEZ pad on the pineskin interface of the FGF-2eapatite-coated titanium screws. The þCEZ pads were prepared by mixing PCL and CEZ in 1,4-dioxane, followed by freeze-drying and compaction. They were analyzed regarding their surface structure, in vitro CEZ release profile, and bactericidal activity. The FGF-2eapatite-coated screws were implanted percutaneously in bilateral rabbit proximal tibial metaphysesdwith and without the þCEZ paddfor 4 weeks (n ¼ 20). The þ CEZ pads consisted of a porous matrix of PCL in which CEZ was embedded. The CEZ-release profile showed an initial burst on Day 1 and a sustained release lasting for 30 days. The þCEZ pad retained its
bactericidal activity against Staphylococcus aureus after preincubation on an agar plate for 7 days. Based on visual inspection, the pin tract infection rate was successfully reduced from 72.2% to 15.0% with the þCEZ pad ( p < 0.05), which reduced the bacterial count, especially S.aureus ( p < 0.05). The histological inflammation rate of the soft tissues was also significantly lower with the þCEZ pad than without it ( p < 0.05). The pin tract infection rate was reduced to one-fifth with the þCEZ pad. Using it as described improves infection resistance during percutaneous implantation

Keywords: Cefazolin; External fixation; Fibroblast growth factor-2; Pin tract infection; Poly(ε-caprolactone)

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Informasi Detail

Judul Seri

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

No. Panggil

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Penerbit

: Asia Pacific Knee., 2014

Deskripsi Fisik

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology 1 (2014) 54e61

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Sport And Kesehatan

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

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