Diagnostic value of plasma lysophosphatidic acid levels in ovarian cancer patients: A case–control study and updated meta-analysis

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Diagnostic value of plasma lysophosphatidic acid levels in ovarian cancer patients: A case–control study and updated meta-analysis

Liyan Cao [et al.] - Nama Orang;

Aim: We investigated whether plasma levels of lysophosphatidic acid (LPA) could serve as a diagnostic indicatorfor assessing disease progression in ovarian cancer (OC) patients.

Material and Methods: In this study, we enrolled 98 patients with OC, 70 patients with benign ovarian tumors and 75 healthy controls. Plasma levels of LPA and cancer antigen 125 (CA-125) were measured in all study subjects. The diagnostic values of LPA and CA-125 plasma levels were evaluated and an updated metaanalysis was performed to examine the association between LPA plasma levels and OC progression. Statistical analyses were performed with SPSS 18.0 and R 3.1.0 software.

Results:
In our case–control study, OC patients showed significantly higher plasma LPA levels compared to
patients with benign tumors and healthy controls (all P< 0.05). Plasma LPA levels exhibited higher diagnostic sensitivity (P=0.008) and specificity (P=0.042) in detecting OC, compared to an established marker, CA-125.Notably, the sensitivity for early stage OC was significantly higher for plasma LPA levels in comparison toCA-125 (P0.05).

Conclusion:Plasma LPA levels are elevated in OC patients and correlate with disease progression. Further, LPA shows higher sensitivity and specificity in OC diagnosis, compared to CA-125, especially in early stage OC.

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Informasi Detail

Judul Seri: Obstetrics Gynaecology Research
No. Panggil: -
Penerbit: Japan : Jurnal Obstetrics Gynaecology Research.., 2015
Deskripsi Fisik: Jurnal Obstetrics Gynaecology Research. 2015,1951 – 1958
Bahasa: English
ISBN/ISSN: doi:10.1111/jog.1280
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: (2015) Vol. 41, No. 12
Subjek: Obstetrics and Gynecology
Info Detail Spesifik: -
Pernyataan Tanggungjawab: deliza

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FULLTEXT: Diagnostic value of plasma lysophosphatidic acid levels in ovarian cancer patients: A case–control study and updated meta-analysis

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