In vitro anti-inflammatory properties of fermented pepino (Solanummuricatum) milk by 휸-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal modelfor evaluating its effects on hypertension

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In vitro anti-inflammatory properties of fermented pepino (Solanummuricatum) milk by 휸-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal modelfor evaluating its effects on hypertension

Vincent Hung-Shu Chang - Nama Orang; Tsai-Hsin Chiub - Nama Orang; Szu-Chieh Fub - Nama Orang;

BACKGROUND: The objectives of this study were to determine the invitro anti-inflammatory and invivo antihypertensive effectsof fermented pepino (Solanum muricatum) milk byLactobacillus brevis with the goal of developing functional healthy products. The inflammatory factors effermented pepino milk withL. brevis were assessed in RAW 264.7 macrophages, including nitric
oxide (NO) production. Inflammatory factor genes of cyclooxygenase (COX)-1 and−2, and tumornecrosis factor (TNF)-휶 were also assayed by a reverse transcription–polymerase chain reaction (RT-PCR).

RESULTS: Results showed that fermented PE inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with 150 mg mL−1 fermented PE completely blocking LPS-induced NO production. The mRNA expressions of COX-1, COX-2,and iNOS were attenuated by treatment with higher concentrations of fermented PE (150 mg/ml). Cells treated with fermented pepino extract (PE) (100 ng mL−1) exhibited strikingly decreased LPS-induced expression of TNF-휶mRNA. During the feeding
trial, rats treated with 10% fermented pepino milk (100훍g2.5mL−1) and 100% fermented pepino milk (1000훍 g2.5mL−1)exhibited significant decreases in the systolic blood pressure.

CONCLUSION: Our results showed that fermented pepino milk has wide potential applications for development as a health food.

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Judul Seri: Sci Food Agric
No. Panggil: -
Penerbit: Taiwan : Society of Chemical Industry, www.soci.org., 2015
Deskripsi Fisik: J Sci Food Agric 2016; 192–198
Bahasa: English
ISBN/ISSN: DOI 10.1002/jsfa.708
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: (2016) 96
Subjek: Science Food Agriculture
Info Detail Spesifik: -
Pernyataan Tanggungjawab: deliza

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