e-journal

Pharmacogenetics of analgesic drugs

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Summary points
•• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complexphenomena and are partly genetically predetermined.
•• Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one ofthe most valuable but equally dangerous groups of medications.
•• While pharmacokinetic properties of drugs, metabolism in particular, have been scrutinised by genotype–phenotype correlation studies, the clinical significance of inherited variants in genes governing pharmacodynamics of analgesics remains largely unexplored (apart from the μ-opioid receptor).
•• Lack of replication of the findings from one study to another makes meaningful personalised analgesic regime still a distant future.
•• This narrative review will focus on findings related to pharmacogenetics of commonly used analgesic medications and highlight authors’ views on future clinical implications of pharmacogenetics in the context of pharmacological treatment of chronic pain.

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Ketersediaan

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Informasi Detail

Judul Seri

Pain

No. Panggil

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Penerbit

: SAGE, British Journal of Pain.,

Deskripsi Fisik

British Journal of Pain 7(4) 189– 208 © The British Pain Society 2013

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

(2013), 7(4)

Subjek

Pain

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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