e-journal

Weighing the balance: how analgesics used in chronic pain influence sleep?

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Abstract:
Pain and sleep share a bidirectional relationship, with each influencing the other. Several excellent reviews have explored this relationship. In this article, we revisit the evidence and explore existing research on this complex inter-relationship. The primary focus of the article is on the pharmacological treatment of chronic non-malignant pain and the main purpose is to review the effect of various pharmacological agents used in the management of chronic pain on sleep. This has not been comprehensively done before. We explore the clinical use of these agents, their impact on sleep architecture and sleep physiology, the mechanism of action on sleep parameters and sleep disorders associated with these agents. Pharmacological classes reviewed include antidepressants, opioid analgesics, anti-epileptics, cannabinoids and non-steroida anti-inflammatory agents, drugs most commonly used to manage chronic pain. The objective is to help
health professionals gain better insight into the complex effect that commonly used analgesics have
on an individual’s sleep and how this could impact on the effectiveness of the drug as an analgesic. We conclude that antidepressants have both positive and negative effects on sleep, so do opioids, but in the latter case the evidence shifts towards the counterproductive side. Some anticonvulsants are sleep sparing and non-steroidal anti-inflammatory drugs (NSAIDs) are sleep neutral. Cannabinoids remain an underexplored and researched group.

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Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

Pain

No. Panggil

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Penerbit

: SAGE, British Journal of Pain., 2014

Deskripsi Fisik

British Journal of Pain 2014, Vol 8(3) 107– 118 © The British Pain Society 2014

Bahasa

English

ISBN/ISSN

DOI: 10.1177/2049463

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

(2014), Vol 8(3)

Subjek

Pain

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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