e-journal

Splice variation of the mu-opioid receptor and its effect on the action of opioids

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Summary points
1. An individual’s response to opioids is influenced by a complex combination of genetic, molecular and phenotypic factors.
2. Intra- and inter-individual variations in response to mu opioids have led to the suggestion that muopioid receptor subtypes exist.
3. Scientists have now proven that mu-opioid receptor subtypes exist and that they occur through a
mechanism promoting protein diversity, called alternative splicing.
4. The ability of mu opioids to differentially activate splice variants may explain some of the clinical differences observed between mu opioids.
5. This article examines how differential activation of splice variants by mu opioids occurs through alternative mu-opioid receptor binding, through differential receptor activation, and as a result of the distinct distribution of variants located regionally and at the cellular level.

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Ketersediaan

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Informasi Detail

Judul Seri

Journal of Pain

No. Panggil

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Penerbit

: SAGE, British Journal of Pain., 2014

Deskripsi Fisik

British Journal of Pain 2014, Vol. 8(4) 133– 138 © The British Pain Society 2014

Bahasa

English

ISBN/ISSN

DOI: 10.1177/2049463

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

(2014), Vol. 8(4)

Subjek

Pain

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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