e-journal

Effects of Lithium Nano-Scaled Particles on Local and Systemic Structural and Functional Organism Transformations Under Tumour Growth

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The results of a study of structural and metabolic changes in CBA mice with hepatocellular carcinoma caused by lithium carbonate nano-sized particles are presented. Light microscopy, electron microscopy and other biochemicalmethodswere used to showthat injection of lithiumcarbonate nano-sized particles to the periphery of the tumour results in enhanced destructive processes within the tumour. The number of neutrophils and macrophages in the tumour increased,whereas the density of blood vessels and haemoglobin concentration were reduced; the extent of tumour necrosis lipid peroxidation and production of nitric oxide was also increased. At the same time, the activity of antioxidant enzymes including superoxide dismutase and catalase remained the same. The introduction of lithium carbonate nano-scaled particles protects vital organs including the heart and lungs from the damaging effect of secondary products of lipid
peroxidation.

Keywords:
Lithium carbonate nano-scaled particles Hepatocellular carcinoma Lipid peroxidation Necrosis Organ structure

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Informasi Detail

Judul Seri

Achievements in the Life Sciences

No. Panggil

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Penerbit

: Elsevier., 2014

Deskripsi Fisik

Achievements in the Life Sciences 8 (2014) 101–111

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

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