e-journal

CressInt: A user-friendly web resource for genome-scale explorationof gene regulation in Arabidopsis thaliana

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tThe thale cress Arabidopsis thaliana is a powerful model organism for studying a wide variety of biologicalprocesses. Recent advances in sequencing technology have resulted in a wealth of information describingnumerous aspects of A. thaliana genome function. However, there is a relative paucity of computationalsystems for efficiently and effectively using these data to create testable hypotheses. We present CressInt,a user-friendly web resource for exploring gene regulatory mechanisms in A. thaliana on a genomic scale.The CressInt system incorporates a variety of genome-wide data types relevant to gene regulation, includ-ing transcription factor (TF) binding site models, ChIP-seq, DNase-seq, eQTLs, and GWAS. We demonstratethe utility of CressInt by showing how the system can be used to (1) Identify TFs binding to the promoterof a gene of interest; (2) identify genetic variants that are likely to impact TF binding based on a ChIP-seqdataset; and (3) identify specific TFs whose binding might be impacted by phenotype-associated variants.

Keywords:ArabidopsisFunctional genomicsTranscription factorsGene regulationSystems biologyWeb serverComputational tools

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Informasi Detail

Judul Seri

Current Plant Biology

No. Panggil

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Penerbit

: Elsevier., 2015

Deskripsi Fisik

Current Plant Biology 3-4 (2015) 48–55

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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