e-journal

Detection of flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus

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a b s t r a c t:
Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide) is a non-steroidal drug that has a specific anti-androgenic activity so that it is used in the treatment of prostate cancer. A simple method for extraction and detection of flutamide from pharmaceutical forms are reported using Soxhlet apparatus combined electrospray ionization tandem mass spectrometry (ESI()-MSn, n = 14) in negative ion mode. Spectra show a fingerprint peaks corresponding to flutamide. Propanamide moiety plays important role in structure elucidation. The diagnostic ions produced a useful fingerprint maps to identify flutamide in unknown samples. Furthermore, the proposed ions may help in the metabolite studies of the drug. The method proposed here is easy, cheap and applicable for large quantity.

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Ketersediaan

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Informasi Detail

Judul Seri

Anality Chemistry

No. Panggil

-

Penerbit

: Elsevier., 2015

Deskripsi Fisik

Anality Chemistry esearch 3 (2015), 01.001

Bahasa

English

ISBN/ISSN

Doi: 101016/j.ancr.2

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

-

Edisi

(2015), 3

Subjek

ANALISIS KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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