e-journal

Perilipin-1 in Hemodialyzed Patients: AssociationWith History of Coronary Heart Disease and Lipid Profile

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Abstract: Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six HD patients and 28
healthy volunteers were enrolled into the study. Ten HD patients suffered from coronary heart disease (CHD). Perilipin-1, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), body mass index, albumin, geriatric nutritional
risk index, normalized protein catabolic rate, interleukin-6 (IL-6) and tumor necrosis factor-a(TNF-a) were measured. Perilipin-1 did not differ between HD patients and healthy volunteers. IL-6 andTNF-a were higher inHDpatients.The evaluated nutritional markers and the markers of inflammation
did not differ betweenHDpatients with high perilipin-1 levels and HD patients with low perilipin-1 levels. Regarding the lipid profile, only HDL-C differed between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels, and it was higher in the first subgroup.
Perilipin-1 was significantly higher in HD patients without CHD. Perilipin-1 is detectable in the serum of HD patients and it is associated with increased HDL-C and decreased incidence of CHD.

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Ketersediaan

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Informasi Detail

Judul Seri

Therapeutic Apheresis and Dialysis

No. Panggil

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Penerbit

: ., 2012

Deskripsi Fisik

Therapeutic Apheresis and Dialysis 2012; 16(4):355–360

Bahasa

English

ISBN/ISSN

doi:10.1111/j.1744-9

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

-

Edisi

2012; 16(4)

Subjek

TERAPI
APHERESIS DAN DIALYSIS

Info Detail Spesifik

-

Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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