e-journal

Cinacalcet Hydrochloride Therapy for Secondary Hyperparathyroidism in Hemodialysis Patients

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Abstract: This study compared the efficacy of a cinacalcetbased regimen with unrestricted conventional therapy(vitamin D and phosphate binders) for achieving Kidney Disease Outcome Quality Initiative (K/DOQI) targets for dialysis patients. In this multicenter, prospective study,
hemodialysis patients with poorly controlled secondary hyperparathyroidism (SHPT) were randomized to receive a cinacalcet-based regimen (n = 55) or a conventional therapy (n = 27). Doses of cinacalcet, vitamin D sterols, and phosphate binders were adjusted during a 12-week dosetitration
phase to achieve intact parathyroid hormone (iPTH) levels  31.8 pmol/L. The primary end point was the percentage of patients with values in this range during a 24-week efficacy-assessment phase. The clinical response to 36-week cinacalcet treatment was evaluated. A dual energy X-ray absorptiometry was performed before and after 36 weeks of cinacalcet therapy. Fifty-eight percent of the cinacalcet group reached the primary end point, as compared with 19% of the conventional therapy group (P = 0.001). A higher percentage of patients receiving the cinacalcet-based regimen versus conventional therapy achieved the targets for calcium, phosphorus and Ca ¥ P. Achievement of targets was greatest in patients with less
severe disease (intact PTH range, 31.8 to 53 pmol/L). Cinacalcet therapy increased proximal femur bone mineral density (BMD), but did not affect the lumbar spine. Itching intensity decreased significantly. Cinacalcet based treatment facilitates achievement of the K/DOQI targets for iPTH and bone mineral metabolism compared with conventional therapy in hemodialysis patients. Suppressionof iPTH with cinacalcet reverses bone loss in the proximal femur. Cinacalcet alleviated itching.

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Ketersediaan

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Informasi Detail

Judul Seri

Therapeutic Apheresis and Dialysis

No. Panggil

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Penerbit

: Therapeutic Apheresis and Dialysis © 2011 International Society for Apheresis., 2011

Deskripsi Fisik

Therapeutic Apheresis and Dialysis 15(6):547–555, 2011

Bahasa

English

ISBN/ISSN

doi: 10.1111//j.1744

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

(2011): 15(6)

Subjek

TERAPI
APHERESIS DAN DIALYSIS

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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