e-journal

Uremic Toxins and Oral Adsorbents

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Abstract:
Uremic toxins are associated with various disorders in patients with end-stage renal disease and it is difficult to remove some of these toxins by dialysis. Since some uremic toxins are generated by bacterial metabolites in the colon, oral adsorbents that interfere with the absorption of
uremic toxins or their precursors are believed to prevent their accumulation in the body. AST-120 adsorbs various uremic retention solutes in the gastrointestinal system and has potential for providing clinical benefit. Sevelamer hydrochloride binds some harmful compounds in addition to phosphate and seems to have pleiotropic effects that include lowering serum LDL cholesterol levels and reduction of inflammation. The effect of sevelamer hydrochloride on indoxyl sulfate and p-cresol has been shown in an in vitro study; however, in vivo studies in mice or humans did
not demonstrate this effect on protein-binding uremic toxins. Oral adsorbents are thus one of the important modalities in the treatment of uremic syndrome.

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Ketersediaan

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Informasi Detail

Judul Seri

Therapeutic Apheresis and Dialysis

No. Panggil

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Penerbit

: Jurnal Therapeutic Apheresis and Dialysis., 2011

Deskripsi Fisik

Therapeutic Apheresis and Dialysis 15(2):132–134

Bahasa

English

ISBN/ISSN

doi: 10.1111/j.1744-

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

15(2), 2011

Subjek

Therapeutic Apheresis and Dialysis

Info Detail Spesifik

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Pernyataan Tanggungjawab

deliza

Versi lain/terkait

Lampiran Berkas

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