e-book

Enzyme-based computing systems

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The use of biomolecular systems for processing information, performing logic operations, computational operations, and even automata performance is a rapidly developing research area. The entire field was named with the general buzzwords, “biomolecular computing” or “biocomputing.” Exciting advances in the area include the use of various biomolecular systems including proteins/enzymes, DNA, RNA, DNAzymes, antigens/antibodies, and even whole biological (usually microbial) cells operating as “hardware” for unconventional computing. The present book concentrates on enzymatic systems, which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in the enzyme-based biocomputing, mimicking Boolean
logic gates, has been motivated by potential applications in biotechnology and medicine. Furthermore, novel biosensor concepts have been contemplated with multiple inputs processed biochemically before the final output is coupled to transducing electronic or optical systems. These applications have warranted recent emphasis on networking of enzyme logic gates. First few gate networks have been experimentally realized, including coupling, for instance, to signal-responsive electrodes for signal readout. In order to achieve scalable, stable network design and functioning, considerations of noise propagation and control have been initiated as a new research direction. Optimization of single enzyme-based gates for avoiding analog noise amplification has been explored, as were certain network optimization concepts. The book reviews and exemplifies these developments, as well as offers an outlook for possible future research foci. The latter include design and uses of non-Boolean network elements, e.g., filters, as well as other developments motivated by potential novel biosensor and biotechnology applications. The most important feature of
the enzyme biocomputing systems is their operation in biochemical and even biological environment. Many different applications of these systems, in addition to unconventional computation, are feasible, while their biosensor/biomedical use is obviously one of the most important applications. Interfacing of biological systems with biosensors, “smart” signal-responsive materials, and bioelectronic devices is of highest importance for future developments in the area of biomolecular computing

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

Weinheim, Germany : John Wiley & Sons, Ltd.., 2019

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

9783527819997

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

Evgeny Katz

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