Abstract—The aim of this paper is to detail the development of a novel tracking framework that is able to extract the cell motility indicators and to determine the cellular division (mitosis) events in large time-lapse phase-contrast image sequences. To address the challenges induced by nonstructured (random) motion, cellular agglomeration, and cellular mitosis, the process of automatic (unsu…
The Gene Ontology (GO) is the leading project to organize biological knowledge on genes and their products in a formal and consistent way across genomic resources. This has had a profound impact at several levels. First, such standardization has made possible the integration of multiple resources and sources of knowledge, thereby increasing their discoverability and simplifying their usage.…
One of my most exciting educational experiences was my introductory molecular biology course in graduate school. My professor used no textbook, but assigned us readings directly from the scientifi c literature. It was challenging, but I found it immensely satisfying to meet the challenge and understand, not only the conclusions, but how the evidence supported those conclusions. When I starte…
THE NEW EDITION OF MOLECULAR BIOLOGY OF THE GENE appears in this, its 7th edition, on the 60th anniversary of the discovery of the structure of DNA in 1953, an occasion celebrated by our cover design. The double-helical structure, held together by specific pairing between the bases on the two strands, has become one of the iconic images of science. The image of the microscope was perhaps th…