Abstract—Largecollectionsofelectronicpatientrecordsprovide abundantbutunder-exploredinformationonthereal-worlduseof medicines. Although they are maintained for patient administration, they provide a broad range of clinical information for data analysis. One growing interest is drug safety signal detection from these longitudinal observational data. In this paper, we proposed two novel algorit…
In this report, we critically reviewed selected intrinsic physicochemical properties of engineered nanomaterials (ENMs) and their role in the interaction of the ENMs with the immediate surroundings in representative aquatic environments. The behavior of ENMs with respect to dynamic microenvironments at the nanoebioeeco interface level, and the resulting impact on their toxicity, fate, and e…
Titanium dioxide nanoparticles (TiO2-NPs,
The objective of this study was to develop an in vitroein vivo correlation (IVIVC) model for hydrophilic matrix extended-release (ER) propranolol dosage formulations. The in vitro release characteristics of the drug were determined using USP apparatus I at 100 rpm, in a medium of varying pH (from pH 1.2 to pH 6.8). In vivo plasma concentrations and pharmacokinetic parameters in male beagle …
This study wasan evaluation of the Health Promoting School (HPS) programin Taiwan and its effectiveness in enhancing students’ knowledge and abilities with regard to correct medication usage. In 2011, baseline and follow-up self-administered online surveys were received from 3520 middle-school and primary students from intervention schools, and 3738 students from comparison primary and se…
The subject matter covered in introductory chemistry classes at the middle and high school levels tends to be fairly traditional and relatively consistent from school to school. Topics that are typically covered in such classes include atomic theory, chemical periodicity, ionic and covalent compounds, equation writing, stoichiometry, and solutions. While these topics are essential for students …
Introduction. The only curative therapeutic approach for renal cell carcinoma (RCC) is surgery. Laparoscopic surgery for RCC has become an established surgical procedure with equivalent cancer-free survival rate, following the same surgical oncological principles as open surgery. Metastatic RCC of the gallbladder is a rare phenomenon. Hence, there are few reports regarding their management. Cas…