Abstract—The analysis and characterization of biomedical image data is a complex procedure involving several processing phases, such as data acquisition, preprocessing, segmentation, feature extraction, and classification. The proper combination and parameterization of the utilized methods are heavily relying on the given image dataset and experiment type. They may thus necessitate advanced i…
Abstract—Thedevelopmentofasystemfortheautomatic,objective, and reliable detection of cough events is a need underlined by the medical literature for years. The benefit of such a tool is clear as it would allow the assessment of pathology severity in chronic cough diseases. Even though some approaches have recently reportedsolutionsachievingthistaskwitharelativesuccess,thereis stillnostandard…
Abstract—Sleep onset latency (SOL) is an objective indicator of sleepiness and is being used clinically as a diagnostic tool for sleep deprivation.Thisstudyproposesanewandlessintrusiveapproach toestimateSOLbasedonthebloodpressure(BP)regulatoryreflex mechanism.Wehypothesizedthatthearterialbaroreflex,onekind of reflex mechanism for BP regulation, maintains the toning-down effect sleep has on…
Abstract—A method for the classification of finger movements for dexterous control of prosthetic hands is proposed. Previous research was mainly devoted to identify hand movements as these actionsgeneratestrongelectromyography(EMG)signalsrecorded from the forearm. In contrast, in this paper, we assess the use of multichannel surface electromyography (sEMG) to classify individual and combine…
Abstract—Minimally or noninvasive continuous glucose monitors estimate plasma glucose from compartments alternative to blood, and may revolutionize the management of diabetes. However, the accuracy of current devices is still poor and it may partly depend on low performance of the implemented calibration algorithm. Here, a new adaptive calibration algorithm based on a population local-model-b…
Abstract—In this paper, we present an autocontext model (ACM)-basedautomaticliversegmentationalgorithm,whichcombines ACM, multiatlases, and mean-shift techniques to segment liver from 3-D CT images. Our algorithm is a learning-based method and can be divided into two stages. At the first stage, i.e., the training stage, ACM is performed to learn a sequence of classifiers in each atlas space…
Abstract—Inrecentyears,wehavewitnessedarapidsurgeinassisted living technologies due to a rapidly aging society. The aging population,theincreasingcostofformalhealthcare,thecaregiver burden, and the importance that the individuals place on living independently,allmotivatedevelopmentofinnovative-assistedliving technologies for safe and independent aging. In this survey, we will summarize the em…
Abstract—The left ventricular assist device is a rotary mechanicalpumpthatisimplantedinpatientswithcongestiveheartfailure tohelptheleftventricleinpumpingbloodinthecirculatorysystem. However,usingsuchadevicemayresultinaverydangerousevent, called ventricular suction, that can cause ventricular collapse due to overpumping of blood from the left ventricle when the rotational speed of the pump is …
Abstract—Current clinical practice involves classification of biopsiedorresectedtumortissuebasedonahistopathologicalevaluation by a neuropathologist. In this paper, we propose a method for computer-aided histopathological evaluation using mass spectrometry imaging. Specifically, mass spectrometry imaging can be used to acquire the chemical composition of a tissue section and, hence, provide…
Abstract—The aim of this paper is to detail the development of a novel tracking framework that is able to extract the cell motility indicators and to determine the cellular division (mitosis) events in large time-lapse phase-contrast image sequences. To address the challenges induced by nonstructured (random) motion, cellular agglomeration, and cellular mitosis, the process of automatic (unsu…
Abstract—This study presents applying recurrence quantificationanalysis(RQA)onEEGrecordingsandtheirsubbands:delta, theta,alpha,beta,andgammaforepilepticseizuredetection.RQA isadoptedsinceitdoesnotrequireassumptionsaboutstationarity, lengthofsignal,andnoise.ThedecompositionoftheoriginalEEG into its five constituent subbands helps better identification of the dynamical system of EEG signal. …
Abstract—This paper presents a wearable biopatch prototype for body surface potential measurement. It combines three key technologies,includingmixed-signalsystemonchip(SoC)technology, inkjet printing technology, and anisotropic conductive adhesive(ACA)bondingtechnology.Anintegralpartofthebiopatchisa low-powerlow-noiseSoC.TheSoCcontainsatunableanalogfront end, a successive approximation regist…
Abstract—In this paper, we propose a cascade-AdaBoostsupport vector machine (SVM) classifier to complete the triaxial accelerometer-basedfalldetectionmethod.Themethodusestheacceleration signals of daily activities of volunteers from a database and calculates feature values. By taking the feature values of a sliding window as an input vector, the cascade-AdaBoost-SVM algorithm can self-constr…
Abstract—Elasticity is an important indicator of tissue health, with increased stiffness pointing to an increased risk of cancer. We investigated a tissue inclusion characterization method for the applicationofearlybreasttumoridentification.Atactilesensation imagingsystem(TSIS)isdevelopedtocaptureimagesoftheembeddedlesionsusingtotalinternalreflectionprinciple.Fromtactileimages,wedevelopedan…
Abstract—In order to understand the brain, we need to first understand the morphology of neurons. In the neurobiology community, there have been recent pushes to analyze both neuron connectivity and the influence of structure on function. Currently, a technical roadblock that stands in the way of these studies is the inability to automatically trace neuronal structure from microscopy. On th…
Abstract—We investigate the use of fractal analysis (FA) as the basis of a system for multiclass prediction of the progression of glaucoma. FA is applied to pseudo 2-D images converted from 1-D retinal nerve fiber layer data obtained from the eyes of normal subjects, and from subjects with progressive and nonprogressive glaucoma. FA features are obtained using a box-counting method and a mul…
Abstract—Mathematical modeling of cardiac electrical signals facilitates the simulation of realistic cardiac electrical behaviors, the evaluation of algorithms, and the characterization of underlying space-time patterns. However, there are practical issues pertinent to model efficacy, robustness, and generality. This paper presents a multiscale adaptive basis function modeling approach tocha…
Abstract—RNA interference (RNAi) is considered one of the most powerful genomic tools which allows the study of drug discovery and understanding of the complex cellular processes by high-content screens. This field of study, which was the subject of 2006 Nobel Prize of medicine, has drastically changed the conventionalmethodsofanalysisofgenes.Alargenumberofimageshave been produced by the RNA…
Abstract—In this paper, a social health support system is developed to assist both anterior cruciate ligament (ACL) patients and clinicians on making better decisions and choices for ACL reconstruction and rehabilitation. By providing a good platform to enablemoreeffectivesharingofpersonalexpertiseandACLtreatments,oursocialhealthsupportsystemcanallow:1)ACLpatients toidentifythebestmatchingsoc…
Abstract—Cadence or stride frequency is an important parameter being controlled in gait training of neurologically impaired subjects. The aim of this study was to examine the effects of cadencevariationonmuscleactivationpatternsduringrobot-assisted unimpaired gait using dynamic simulations. A 2-D musculoskeletal model of human gait was developed considering eight major muscle groups along wit…
Abstract—A number of automated neonatal seizure detectors have been proposed in recent years. However, there exists a large variability in the morphology of seizure and background patterns, both across patients and over time. This has resulted in relatively poor performance from systems which have been tested over large datasets. Here, the benefits of employing a pattern recognition approach…
Abstract—In this paper, a method using higher order statistical moments of EEG signals calculated in the empirical mode decomposition (EMD) domain is proposed for detecting seizure and epilepsy. The appropriateness of these moments in distinguishing the EEG signals is investigated through an extensive analysis in the EMD domain. An artificial neural network is employed as the classifier of …
Abstract—Thephysiologicalandactivitystrainindex(PASI)has beendevelopedtoimprovetheonlinedecisionsupportforworkers exposed to heat stress. Fire fighters (smoke divers) which are exposedtobothheat-stressandhigh-risksituationshavebeenusedas test case. PASI combines a modified version of the relatively wellknown physiological strain index (PSI) with activity data from accelerometers. The algori…
Abstract—Traditional signal processing methods cannot detect interspersed repeats and generally cannot handle nonstationary signals. In this paper, we propose a new method for periodicity detection in protein sequences to locate interspersed repeats. We first apply the autoregressive model with a sliding window to find possible repeating subsequences within a protein sequence. Then, we util…
Abstract—In the diagnosis of skin melanoma by analyzing histopathological images, the detection of the melanocytes in the epidermis area is an important step. However, the detection of melanocytes in the epidermis area is difficult because other keratinocytesthatareverysimilartothemelanocytesarealsopresent. Thispaperproposesanovelcomputer-aidedtechniqueforsegmentation of the melanocytes in t…
Abstract—Largecollectionsofelectronicpatientrecordsprovide abundantbutunder-exploredinformationonthereal-worlduseof medicines. Although they are maintained for patient administration, they provide a broad range of clinical information for data analysis. One growing interest is drug safety signal detection from these longitudinal observational data. In this paper, we proposed two novel algorit…
Abstract—Monitoring breath and identifying breathing movementshavesettledimportanceinmanybiomedicalresearchareas, especially in the treatment of those with breathing disorders, e.g., lungcancerpatients.Moreover,virtualreality(VR)revolutionand their implementations on ubiquitous hand-held devices have a lot ofimplications,whichcouldbeusedasasimulationtechnologyfor healing purposes. In this pap…
Abstract—Inordertoimprovethecorrectionaccuracyontongue colorsbyuseofaMunsellcolorchecker,thisresearchaimstodesign a new colorchecker by aid of tongue color space. Three essential issues leading to the development of this space-based colorchecker areelaboratelyinvestigatedinthisstudy.First,basedonalargeand comprehensive tongue database, tongue color space is established bywhichallvisiblecolors…
Abstract—Thispaperintroducesalow-complexityalgorithmfor the extraction of the fiducial points from the electrocardiogram (ECG). The application area we consider is that of remote cardiovascular monitoring, where continuous sensing and processingtakesplaceinlow-power,computationallyconstraineddevices, thusthepowerconsumptionandcomplexityoftheprocessingalgorithms should remain at a minimum lev…
Abstract—Thegrowingneedforperforminglarge-scaleandlowcost biomedical studies has led organizations to promote the reuse of patient data. For instance, the National Institutes of Health in the U.S. requires patient-specific data collected and analyzed in thecontextofGenome-wideAssociationStudies(GWAS) tobedepositedintoabiorepositoryandbroadlydisseminated.Whileessential to comply with regulati…
Abstract—A new thermal imaging framework with unique featureextractionandsimilaritymeasurementsforfacerecognitionis presented.Theresearchpremiseistodesignspecializedalgorithms thatwouldextractvasculatureinformation,createathermalfacial signature, and identify the individual. The proposed algorithm is fullyintegratedandconsolidatesthecriticalstepsoffeatureextractionthroughtheuseofmorphological…
Abstract—Public m-health is a new medical service under intensive development, which provides unobtrusive monitoring of people’shealthconditionsfromanywhereatanytimetoenabledetection of deteriorating health conditions before severe discomfort or disability occur. A key challenge in practical implementation of public m-health is the use of shared license-free spectrum by body area networks (…
Abstract—This paper describes an echocardiogram coding method that takes into account the visualization modes in order tocompressefficientlytheechocardiogram,amethodologytoevaluate compressed echocardiograms, and the evaluation of the compression method using the proposed evaluation methodology. The compressionmethodtakesadvantageoftheparticularcharacteristicsofeachvisualizationmodeandusesdi…
Abstract—In this paper, a feasibility study where small wireless devices are used to classify some typical user’s positions in the bed is presented. Wearable wireless low-cost commercial transceivers operatingat2.4GHzaresupposedtobewidelydeployedinindoor settings and on people’s bodies in tomorrow’s pervasive computing environments. The key idea of this study is to leverage their presen…
Abstract—Coronary heart disease (CHD) caused by hardening of artery walls due to cholesterol known as atherosclerosis is responsible for large number of deaths worldwide. The disease progression is slow, asymptomatic, and may lead to sudden cardiac arrest, stroke, or myocardial infraction. Presently, imaging techniques are being employed to understand the molecular and metabolic activity of a…
Abstract—Colonoscopy is the most popular screening tool for colorectal cancer. Recent studies reported that retroflexion during colonoscopy helped to detect more polyps. Retroflexion is an endoscope maneuver that enables visualization of internal mucosa along the shaft of the endoscope, enabling visualization of the mucosa area that is difficult to see with typical forward viewing. This pa…
Abstract—Data-driven techniques have recently drawn significant interest in the predictive modeling of subcutaneous (s.c.) glucose concentration in type 1 diabetes. In this study, the s.c. glucose prediction is treated as a multivariate regression problem, whichisaddressedusingsupportvectorregression(SVR).Theproposed method is based on variables concerning: 1) the s.c. glucose profile; 2) th…
Abstract—We propose a novel joint probabilistic model that correlates a new probabilistic shape model with the corresponding global intensity distribution to segment multiple abdominal organs simultaneously. Our probabilistic shape model estimates the probability of an individual voxel belonging to the estimated shape of the object. The probability density of the estimated shape is derived fr…
Abstract—In this paper, lossless and near-lossless compression algorithms for multichannel electroencephalogram (EEG) signals arepresentedbasedonimageandvolumetriccoding.Multichannel EEG signals have significant correlation among spatially adjacent channels; moreover, EEG signals are also correlated across time. Suitable representations are proposed to utilize those correlations effectively.…
Abstract—Content-basedhistologyimageretrievalsystemshave shown great potential in supporting decision making in clinical activities, teaching, and biological research. In content-based image retrieval, feature combination plays a key role. It aims at enhancing the descriptive power of visual features corresponding to semantically meaningful queries. It is particularly valuable in histology im…
Abstract—Iris analysis studies the relationship between human health and changes in the anatomy of the iris. Apart from the fact that iris recognition focuses on modeling the overall structure of theiris,irisdiagnosisemphasizesthedetectingandanalyzingoflocal variations in the characteristics of irises. This paper focuses on studyingthegeometricalstructurechangesinirisesthatarecaused by gastro…
Proses pembelajaran adalah merupakan salah satu strategi untuk mentransfer pengetahuan (kebudayaan) dari guru ke sipembelajar. Untuk itu guru yang profesional berusaha mengemas materi pembelajaran sebaik mungkin agar apa yang diajarkan atau disampaikan kepada peserta didik dapat dikuasai secara maksimal oleh peserta didik. Namun kenyataan yang terjadi pada diri peserta didik, tidak seluruh…
Pandangan monoisme maupun dualisme sama-sama sepakat bahwa individu merupakan suatu kesatuan jasmani dan rohani. Sebab tidak mungkin seseorang berpikir tanpa ada unsur kemauan dan tidak mungkin seseorang menginginkan sesuatu tanpa ada unsur berpikir. Di samping itu manusia tidak dapat hidup sendiri tetapi juga membutuhkan pihak lain untuk dapat bekerjasama dalam kehidupan ini. Jadi dapat …
This companion in theoretical econometrics is the first in a series of companions in economics published by Blackwell. The emphasis is on graduate students of econometrics and professional researchers who need a guide, a friend, a companion to lead them through this exciting yet ever growing and expanding field. This is not a handbook of long chapters or exhaustive surveys on the subject. These…
There are many different ways to do the philosophy of biology. At one end of a spectrum of possibilities would be works of general philosophical interest drawing on biological examples for illustration and support. At the other end would be works that deal only with conceptual and methodological issues that arise within the practice of biology. The strategy of this book is closer to the second …
The purpose of this Companion is threefold: to introduce the history of economic thought, the interpretive problems facing historians of economic thought, and the work of historians of economic thought to interested and competent nonspecialists, including other economists, graduate students, advanced undergraduate students, and lay people (including noneconomists), as well as specialists seekin…
Faxian traveled regions that we now lump together as Asia. He wrote about what he discovered, translated the texts he brought back, suffered aches and pains, felt homesick, returned transformed, and, in turn, transformed the world’s understanding of religion, Buddhism, travel, geography, ritual, art, and many other things. His traveling companions died, left him, joined him, pursued other pat…
The anthropology of education sits at the crossroads of anthropology as a discipline, schooling as a professional field, and education as a perennial human endeavor. As anthropologists of education, we attempt to offer the insights and concepts of anthropology to educational theory and practice, and conversely, to enrich the discipline of anthropology by offering deep inquiry into educational p…
The Gene Ontology (GO) is the leading project to organize biological knowledge on genes and their products in a formal and consistent way across genomic resources. This has had a profound impact at several levels. First, such standardization has made possible the integration of multiple resources and sources of knowledge, thereby increasing their discoverability and simplifying their usage.…