Hypoglycaemic effects of functional tri-peptides from silk in differentiated …

Abstract BACKGROUND: In this study, the tri-peptides Gly-Glu-Tyr (GEY) andGly-Tyr-Gly (GYG), identified previously as active compounds from the silk peptide E5K6, significantly stimulated basal and insulin-mediated glucose uptake by 3T3-L1 fibroblasts in a dose-dependent manner. RESULTS: Synthetic GEY and GYG peptides at a concentration of 500