Role of PGC-1a in muscle function and aging

This article focuses on the current underlying of molecular mechanisms of the peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1a) mediated pathway and discuss possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and ameliorating aging and aging-related diseases. PGC-1a is the master transcription regulator that stimul…