PDMS embedded microneedles as a controlled release system for the eye

Purpose: To demonstrate intraocular drug delivery using a novel device fabricated by embedding hollow glass microneedles within a soft and flexible poly (dimethylsiloxane) (PDMS) substrate for ease of device insertion into the eye. Methods: Hollow glass microneedles (5 mm ID tips), fabricated using standard glass drawing techniques, were assembled into a photolithographically micropatterned PDM…