Interference of ethylene glycol with L-lactate measurement is assay-dependent

Background: Metabolites of ethylene glycol (EG) can cross-react in L-lactate assays, leading to falsely elevated serum lactate levels in case of EG intoxication. In this study, we evaluated the effects of EG and its metabolites on routinely used lactate measuring methods. Methods: Serum aliquots were spiked with either L-lactate, EG or one of its metabolites (all 12.5 mmol/L): glyoxal, glycolat…