Role and mechanism of insulin-like growth factor 2 on the proliferation of hu…

Aim: To study the effect and relevant molecular mechanisms of insulin-like growth factor 2 (IGF2) on the proliferative activity of first trimester human trophoblasts in vitro. Materials and Methods: Extravillous cytotrophoblasts (EVCTs) were isolated and cultured. Cells were cultured with IGF2 at different concentrations and the proliferative activity was measured using methyl thiazolyl tret…