Murine Monoclonal Antibody to Platelet Factor 4/Heparin Complexes as a Potent…

Quality control of the platelet activation assays to diagnose heparin-induced thrombocytopenia (HIT), 14C-serotonin release assay (SRA) and platelet aggregation test (PAT) has yet to be established due to lack of reference standards and the difficulty of obtaining significant amounts of HIT antibodies from patients with HIT. We prepared a murine monoclonal antibody to human platelet factor 4 (h…