Implications of oxidative damage to proteins and DNA in aging and its interve…

In this short review we describe implications of age-related changes of protein and DNA oxidation as a public mechanism of biological aging.Oxidativelymodified protein andDNAhave been demonstrated to increasewith advancing age in rodents. Half-life of proteins is extended andDNArepair activity declines in old animals.Dietary restriction initiated late in life can shorten the half-life of protei…