A simple, selective, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of rabeprazole (RP), pantoprazole (PP), and itopride (IP) has been developed. The compounds were well separated on a Phenomenex C18 (Luna) column (250 mm 4.6 mm, dp ¼ 5 mm) with C18 guard column (4 mm 3 mm 5 mm) with a mobile phase consisting of b…