Epigallocatechin gallate inhibits the HIV reverse transcription step

Background: Epigallocatechin gallate (EGCG), the most abundant catechin in green tea, has been reported to inhibit HIV-1 replication prior to its integration into host DNA via various proposed mechanisms; however, the specific main target(s) of EGCG remain unclear. In this study,we investigated a number of these proposed detailed mechanism(s) using a cell-based model.Methods: Multinuclear act…