Acid-base physiology: new concepts

Abstract The traditional approach to acidebase physiology is based on the HendersoneHasselbalch equation which is derived from the CO2=HCO3
buffer system. However, it is becoming increasingly recognized that this is an incomplete analysis as it focuses on only one of the six reactions involving H þ and can lead to the incorrect assumption that CO2 and HCO3
are independentlyadjusted facto…