e-journal

Research on micro-structure and hemo-compatibility of the artificial heart valve surface

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Abstract.
In order to seek the method to improve the hemo-compatibility of artificial mechanical heart valve, the
surface of rabbit’s heart valve was observed using the scanning electron microscopy (SEM). The results
showed that the dual-scale structure which consists of cobblestones-like structure of 8 umin underside
diameter and 3 um in height, and the fine cilia of about 150 nm in diameter, was helpful to the hemocompatibility of the heart valve. Therefore, the polydimethylsiloxane (PDMS) surface with hierarchical
micro-structure was fabricated using femtosecond laser fabrication technique and soft lithography. At
the same time, the tests of apparent contact angle and platelet adhesion on both smooth and textured
PDMS surfaces were carried out to study their wettability and hemo-compatibility. The results
demonstrated that the surface with textured structure displayed more excellent wettabililty and anticoagulation property than that of smooth surface. The apparent contact angle of textured surface
enhanced from 113.1o to 163.6o and the amount of adsorbed platelet on such surface was fewer, no
distortion and no activation were found.

Keywords: Heart valve, PDMS, Micro-structure, Superhydrophobicity, Hemo-compatibility

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Informasi Detail

Judul Seri

Applied Surface Science

No. Panggil

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Penerbit

London : Elsevier B.V.., 2009

Deskripsi Fisik

Applied Surface Science 255 (2009) 6686–6690

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

agus

Versi lain/terkait

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