e-journal

Identification of biosynthetic intermediates of teaghrelins and teaghrelin-like compounds in oolong teas, and their molecular docking to the ghrelin receptor

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Teaghrelins are unique acylated flavonoid tetraglycosides found in Chin-shin oolong tea,and have been demonstrated to be promising oral ghrelin analogues. The biosynthetic pathway of teaghrelins from quercetin-3-O-rutinoside (rutin) or kaempferol-3-O-rutinoside (nicotiflorin) was proposed to comprise three enzymatic steps according to the identification
of putative intermediates in Chin-shin oolong tea. In addition to the two known teaghrelins in Chin-shin oolong tea, four teaghrelin-like compounds with different attachments of glycosides were identified in various oolong teas. Molecular modeling and docking were used to evaluate theoretically whether the putative biosynthetic intermediates
of teaghrelins and the four teaghrelin-like compounds could be potential candidates of ghrelin analogues. The results showed that the attachment of a coumaroyl group was crucial for these tea compounds to bind to the ghrelin receptor. However, the additional attachment of a rhamnosyl glycoside to the flavonoid backbone of teaghrelinlike compounds at C-7 significantly reduced their binding affinity with the ghrelin receptor.

Keywords:
ghrelin analogues ghrelin receptor molecular docking oolong tea teaghrelin

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Informasi Detail

Judul Seri

Journal Of Food and Drug Analysis

No. Panggil

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Penerbit

Taiwan : Elsevier Taiwan., 2014

Deskripsi Fisik

Journal Of Food and Drug Analysis 22 (2014) 660-670

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Food And Health

Info Detail Spesifik

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Pernyataan Tanggungjawab

Wati/Agus

Versi lain/terkait

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