Abstract: Aims: The aim of this study was to examine the effect of metformin on serum adiponectin and adiponectin receptor-1 (AdipoR1) and evaluate their role in prediction of ovulation in patients with polycystic ovarian syndrome (PCOS). Material and Methods: The study cohort included 68 PCOS patients with clomiphene citrate resistance (group 1) and 28 healthy women as controls (group 2). Ba…
Abstract: Aim: The aim of our study was to examine the association of low pregnancy-associated plasma protein-A (PAPP-A) with adverse pregnancy outcome. Material and Methods: A total of 1640 consecutive pregnant women between 9+5 and 13+6 weeks of pregnancy were recruited. One hundred and thirty women with PAPP-A levels < 0.4 multiple of median were followed till delivery and the outcome info…
Abstract: A 27-year-old woman underwent a first vaginal delivery at our institution. She returned four days after delivery, presenting with abdominal pain and an unexplained drop in her hemoglobin value, without external bleeding. The initial computed tomography abdominal scan revealed an isolated diffuse hemoperitoneum. A laparoscopy did not find the cause of bleeding. A second computed tomog…
Abstract: Aim: To evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage (IRSM) following administration of micronized vaginal progesterone and oral dydrogesterone. Methods: One hundred and thirty-three women (aged 23–40 years) who had had early miscarriages and spontaneous conception participated. Oral dydrogester…
Abstract Aim: To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR). Material and Methods: A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal cl…
Aim: Intermittent assessment of renal artery flow velocity waveforms during the early stages of pregnancymay help in predicting changes in amniotic fluid dynamics. The current study sought to determine the relation of renal artery and umbilical artery flow velocity waveforms with normal pregnancies and pregnancies complicated by either polyhydramnios or oligohydramnios. Material and Methods:…
Aim: To investigate the indications and effectiveness of ovarian transposition before pelvic irradiation. Methods: This was a retrospective analysis of patients with malignancies who underwent ovarian transpositionbefore pelvic irradiation. The collected data included age of patient, type and stage of cancer, details of irradiation treatment, and clinical and biochemical parameters of ovaria…
Aim: The molecular pathogenesis of non-obstructive azoospermia (NOA) is unclear.Our aimwas to identify the genetic susceptibility forNOAin Japanese men by using a combination of transcriptome network analysis and SNPgenotyping. Material and Methods: We searched for candidate genes using RNA transcriptome network analysis of 2611 NOA-related genes that we had previously reported.We analyzed …
Aim: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator against oxidative stress through the induction of antioxidant and cytoprotective genes, such as heme oxygenase 1 (HO-1), glutamyl cysteine ligase catalytic (GCLC), and glutamyl cysteine ligase modulatory (GCLM). Nrf2 signaling is disrupted in pre-eclamptic placentas, although increased oxidative stress is…
Aim: To study the effect and relevant molecular mechanisms of insulin-like growth factor 2 (IGF2) on the proliferative activity of first trimester human trophoblasts in vitro. Materials and Methods: Extravillous cytotrophoblasts (EVCTs) were isolated and cultured. Cells were cultured with IGF2 at different concentrations and the proliferative activity was measured using methyl thiazolyl tret…
Aim: To review and evaluate the efficacy of kidney-tonifying traditional Chinese medicine prescriptions (KT-TCMP) in hypoplastic uterus (HU) treatment. Methods: We searched MEDLINE, the Cochrane Library, CNKI (China National Knowledge Infrastructure),WANFANG and VIP databases until 14 December 2013 independently with two investigators. Randomized controlled trials (RCT) involving KT-TCMP as …
Aim: The aim of the present study was to evaluate the surgical and obstetric results of laparoscopy versus laparotomy in the management of ovarian cyst during pregnancy. Material and Methods: Sixty-nine eligible patients who met our criteria were randomly divided into the laparoscopy group (n = 33) and the laparotomy group (n = 36). The two groups were compared for their surgical and obstetric…
(MPI) in small-for-gestational age (SGA) fetuses during 28–40 weeks of gestation. Material and Methods: Singleton pregnant women during 28–40 weeks of gestation were enrolled. Estimated metal weight was used to classify the subjects into appropriate-for-gestational age (AGA) and SGA groups. The Doppler indices of umbilical and middle cerebral arteries, including amniotic fluid index, were …
Aim: We investigated whether plasma levels of lysophosphatidic acid (LPA) could serve as a diagnostic indicatorfor assessing disease progression in ovarian cancer (OC) patients. Material and Methods: In this study, we enrolled 98 patients with OC, 70 patients with benign ovarian tumors and 75 healthy controls. Plasma levels of LPA and cancer antigen 125 (CA-125) were measured in all study su…
Abstract Aim: This study aimed to compare the hemodynamic profile and efficacy of carbetocin versus intra-umbilical oxytocin in the management of retained placenta following vaginal delivery. Material and Methods: In this randomized clinical study, women with retained placenta for more than 30min were assigned to receive either an i.v. bolus of 100-μg carbetocin (n = 38) or an intra-umbilica…
Abstract: Aim: To compare levator defect, loss of tenting, change in biometric measurements of the levator ani and genital hiatus according to the mode of delivery, length of the labor, Bishop score, birthweight and head circumference immediately after delivery. Methods: One hundred and seventy-one primiparous women who delivered either by vaginal delivery or cesarean were prospectively evalu…
Abstract: Aim: The aim of this study was to identify yolk sac (YS) abnormalities and analyze their relation with different embryonic morphologies detected by ultrasonography in first-trimester missed miscarriage. Material and Methods: This descriptive study was carried out on 204 women with established first-trimester missed miscarriage. Ultrasonography depicted the YS’s diameter, shape, an…
Abstract: To date, numerous studies have searched for candidate molecules or clinical examination methods as potential biomarkers for monitoring intractable diseases, such as carcinomas. Evidence accumulated over the past decade shows that many proteolytic peptides appear in human humoral fluids, including peripheral blood, in association with an individual’s health condition. Although an an…
Abstract: The aim of the present review is to summarize the current evidence on the role of pelvic and para-aortic lymphadenectomy in endometrial cancer. In 1988, the International Federation of Obstetrics and Gynecology recommended surgical staging for endometrial cancer patients. However, 25 years later, the role of lymph node dissection remains controversial. Although the findings of two la…
Aim: The purpose of the present study was to evaluate vaginal fluid b-human chorionic gonadotrophin (b-hCG) for the diagnosis of preterm premature rupture of membranes (PPROM). Material and Methods: An observational cross-sectional study was performed on 123 pregnant women whowere in the third trimester of their gestation (28–37 weeks). The patients were divided into three groups: (i)PPROM…
Aim: The aim of this study was to observe the effect of attenuated Salmonella typhi as a tumor-targeting delivery vector for multidrug-resistance gene (MDR1) small interfering RNA (siRNA). Material and Methods: The cisplatin (DDP)-resistant ovarian cancer cell line SKOV-3/DDPwas established by treatment with gradually increasing concentrations of cisplatin. MDR1 siRNA expression plasmid contai…