In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last deca…
Abstract—Atrial fibrillation (AF) is the most frequent cardiac arrhythmia seen in clinical practice. Several therapeutical approaches have been developed to terminate the AF and the effects are evaluated by the reduction of the wavelet number after the treatments. Most of the previous studies focus on modeling and analysis of the mechanism, and the characteristic of AF. But no one discusses a…
Abstract: Despite abnormal clotting, circuits clot during continuous renal replacement therapy (CRRT) in children with acute liver failure (ALF).We report our experience. All children with ALF needing CRRT were studied over 2 years. Patient and circuit factors associated with circuit use were evaluated.Thirty-one children in liver failure (median age 7.4 years) underwent CRRT, of which 17 (54.8…
Abstract: Accelerated formation and tissue accumulation of advanced glycation end products (AGEs), reflecting cumulative glycemic and oxidative stress, occurs in agerelated and chronic diseases like diabetes mellitus (DM) and renal failure, and contributes to vascular damage. Skin auto fluorescence (AFR), a noninvasive measurement method, reflects tissue accumulation of AGEs. AFR has been repo…
Abstract: Sevelamer hydrochloride (SH) has been reported to aggravate metabolic acidosis and hyperkalemia. This study was performed to evaluate acid–base status and serum potassium changes after replacing SH with lanthanum carbonate (LC) in hemodialysis patients. SH was prescribed for 24 weeks in 14 stable hemodialysis patients and replaced by LC in a similar treatment schedule. Laboratory te…
Abstract: This study compared the efficacy of a cinacalcetbased regimen with unrestricted conventional therapy(vitamin D and phosphate binders) for achieving Kidney Disease Outcome Quality Initiative (K/DOQI) targets for dialysis patients. In this multicenter, prospective study, hemodialysis patients with poorly controlled secondary hyperparathyroidism (SHPT) were randomized to receive a cinac…
Abstract: Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six HD patients and 28 healthy volunteers were enrolled into the study. Ten HD patients suffered from coronary heart disease (CHD). Per…
Abstract: Carotid-femoral pulse wave velocity (cfPWV) is an important predictor of cardiovascular events in the general population and also in hemodialysis (HD) patients. In the general population, cfPWV is strongly associated with age and blood pressure (BP). The best timing and method of BP measurement in HD patients is uncertain. Ambulatory blood pressure measurements (ABPM) have been used …
Abstract: Acute lung injury (ALI) in sepsis is characterized by an increase in microvascular permeability, resulting in pulmonary edema. Several studies have suggested that angiopoietin-1 and -2 play a contributory role in the pathogenesis of ALI. Polymyxin B-immobilized fiber column hemoperfusion is effective for sepsis-induced ALI. We investigated the angiopoietin levels before and after dire…
Abstract This article describes the assessment of the patient for renal transplantation, the perioperative management and the aims in the postoperative period. These patients present a unique set of challenges to the anaesthetist, who has a crucial role in the immediate success of the transplanted organ. Keywords Cold ischaemia time; end-stage renal disease; fluid therapy; induction and mai…
Abstract When grouped with Pacific Islanders, Asian Americans constitute the fastest growing ethnic group in the United States. In this article, the authors provide background information for understanding the diversity and commonalities within Asian American populations and discuss the challenges of initial assessment with clients who identify as Asian Americans. We conclude this article wi…
Abstract Changing social demographics require that psychotherapists and mental health delivery systems become accountable for developing attitudes and skills for working multiculturally. This article immerses the reader in contextual and cultural principles for establishing an initial therapeutic relationship with Latinas/os. These contextual and cultural principles also can be implemented ac…
Abstract Some may view the initial interview as a mechanistic procedure complete with a list of tasks to accomplish. The primary purpose of this article is to deconstruct this perspective and encourage psychotherapists to explore the initial interview through an ethical acculturation lens. Using a case scenario, we demonstrate the need for purposeful reflection to better understand important…
Abstract Initial psychotherapy sessions with adolescents can be very challenging due to the need to balance assessment, relationship building, caretaker/parent management, and case formulation with a client population that sometimes has little motivation for psychotherapy. This article combines empirical evidence, theoretical knowledge, and clinical experience to describe strategies for ho…
The original goal of this research was to develop an empirically based, conceptual model of optimal sexuality. To that end, semistructured, phenomenologically oriented interviews were conducted with 76 key informants. The three participant groups consisted of men and women over the age of 60 who had been married for over 25 years, self-identified members of sexual minority groups, and sex thera…
It is currently estimated that up to 6 million children take psychotropic medications for the treatment of mental health problems. The highest prevalence rates (50–76 %) are typically found among students with special needs, especially among those with ADHD and emotional disturbance. The Individuals with Disabilities Education Act (IDEA) and Section 504 of the Rehabilitation Act of 1973 requi…