The use of biomolecular systems for processing information, performing logic operations, computational operations, and even automata performance is a rapidly developing research area. The entire field was named with the general buzzwords, “biomolecular computing” or “biocomputing.” Exciting advances in the area include the use of various biomolecular systems including proteins/enzymes,…
Abstract: An enzyme-based biofuel cell with a pH-switchable oxygen electrode, controlled by enzyme logic operations processing in situ biochemical input signals, has been developed. Two Boolean logic gates (AND/OR) were assembled from enzyme systems to process biochemical signals and to convert them logically into pH-changes of the solution. The cathode used in the biofuel cell was modifie…
Natural biochemical processes are controlled and regulated by different mechanisms at various levels of complexity involving numerous biochemical and physiological reactions.1 Artificial biocatalytic and particularly bioelectrocatalytic processes used in various bioelectronic devices, such as biosensors, biofuel cells, and bioactuators, are suffering from the lack of the biochemical control and…
ABSTRACT A nanostructured signal-responsive thin hydrogel membrane was coupled with enzyme-based systems to yield “smart” multisignal-responsive hybrid systems with built-in “logic”. The enzyme systems transduce biochemical input signals into structural changes of the membrane, thus resulting in the amplification of the biochemical signals and their transformation into the gated trans…
ABSTRACT The modified electrode for electrocatalytic oxidation of NADH was developed using a pH-switchable redox interface. The operation of the modified electrode was controlled by logic operations performed by enzyme systems processing biochemical input signals. The electrocatalytic oxidation of NADH was activated upon appropriate combinations of the signals processed by the AND/OR logic op…