Natural biochemical processes are controlled and regulated by different mechanisms at various levels of complexity involving numerous biochemical and physiological reactions.1 Artificial biocatalytic and particularly bioelectrocatalytic processes used in various bioelectronic devices, such as biosensors, biofuel cells, and bioactuators, are suffering from the lack of the biochemical control and…
ABSTRACT A nanostructured signal-responsive thin hydrogel membrane was coupled with enzyme-based systems to yield “smart” multisignal-responsive hybrid systems with built-in “logic”. The enzyme systems transduce biochemical input signals into structural changes of the membrane, thus resulting in the amplification of the biochemical signals and their transformation into the gated trans…
ABSTRACT The modified electrode for electrocatalytic oxidation of NADH was developed using a pH-switchable redox interface. The operation of the modified electrode was controlled by logic operations performed by enzyme systems processing biochemical input signals. The electrocatalytic oxidation of NADH was activated upon appropriate combinations of the signals processed by the AND/OR logic op…