To develop novel tumor cell microenvironment stimuli-responsive smart controlledrelease delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and a…
Cancer is the second leading cause of death in the USA according to the American Cancer Society. In the past 5 years, “theranostic nanomedicine”, for both therapeutics and imaging,has shown to be “the right drug for the right patient at the right moment” to manage deadly cancers. This review article presents an overview of recent developments, mainly from the authors’ laboratories, a…
Limnophila aromatica is commonly used as a spice and a medicinal herb in Southeast Asia. In this study, water and various concentrations (50%, 75%, and 100%) of methanol, ethanol,and acetone in water were used as solvent in the extraction of L. aromatica. The antioxidant activity, total phenolic content, and total flavonoid content of the freeze-dried L. aromatica extracts were investigated usi…
A simple, precise, accurate, and selective method is developed and validated for the determination of oleuropein, which is the main phenolic compound in olive leaves. Separation was achieved on a reversed-phase C18 column (5 mm, 150 4.6 mm inner diameter) using a mobile phase consisting of acetonitrile/phosphate buffer pH 3.0 (20:80, v/v), at a flow rate of 1.0 mL/minute and UV detection at 2…
The aim of the present study was to develop a simple and fast screening technique to directly evaluate the bactericidal effects of 5-aminolevulinic acid (ALA)-mediated photodynamic inactivation (PDI) and to determine the optimal antibacterial conditions of ALA concentrations and the total dosage of light in vitro. The effects of PDI on Staphylococcus aureus and Pseudomonas aeruginosa in the pr…
A simple and sensitive electrochemical method for the simultaneous and quantitative detection of ranitidine (RT) and metronidazole (MT) was developed, based on a poly (chromotrope 2B) modified activated glassy carbon electrode (PCHAGCE). The PCHAGCE showed excellent electrocatalytic activity toward the reduction of both RT and MT in 0.1 mol/L phosphate buffer solution (pH 6.0). The peak-to-pea…
Antituberculosis drug-related liver injury (ATLI) is the most prevalent hepatotoxicity in many countries. Whether monitoring liver tests is beneficial to prevent this potentially grave adverse drug reaction (ADR) is open to debate. The Taiwan Drug Relief Foundation (TDRF) was established by the Taiwan Food and Drug Administration to collect severe cases of ADR and carry out drug injury relief t…
To guarantee the safety of chocolate ice cream production, the Hazard Analysis Critical Control Points (HACCP) system was applied to the production process. The biological,chemical, and physical hazards that may exist in every step of chocolate ice cream production were identified. In addition, the critical control points were selected and the critical limits, monitoring, corrective measures, …
The purpose of this study is to evaluate the only available calcium p-aminosalicylate (Ca PAS) commercial product, which is one of the most commonly prescribed non-surveillance products fromthe Bureau of National Health Insurance (BNHI) database in Taiwan. An openrandomized,balanced, two-way crossover study was designed to evaluate the relative bioavailability (F) of a 500 mg Ca PAS F.C. table…
The capability of Chhit-Chan-Than extract powder (CCTEP, 10% aqueous Ocimum gratissimum L. extract) to protect against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity in vivo was investigated. Wistar rats were divided into five groups. Group A was a normal control group given only vehicle; Group B, the hepatotoxic group, was injected intraperitoneally twice a week with …
The pandemic influenza A/H1N1 outbreak resulted in 18,449 deaths in over 214 countries. In Taiwan, the influenza rapid test, an in vitro diagnostic device (Flu-IVD), only requires documented reviews for market approval by the Taiwan Food and Drug Administration. The purpose of this study was to investigate the analytical sensitivity and specificity of Flu-IVDs used in Taiwan. Analytical sensiti…
Carotenoid-rich green leafy vegetables including cilantro, Thai basil leaves, sweet potato leaves, and choy sum were selected to evaluate the effects of water cooking or boiling on their total carotenoid content (TCC), total phenolic content (TPC), and total antioxidant capacity (TAC). The percentage inhibition of peroxidation (%IP), Trolox equivalent antioxidant capacity (TEAC), and metal-chel…
A new analytical method for determining deoxycytidine kinase (dCK) activity in biological milieus using luminescence is reported here. This method, based on utilizing adenosine triphosphate (ATP) as the sole phosphate donor in the kinase reaction and monitoring ATP consumption via a luciferase-based chemiluminescence reaction, is capable of detecting dCK activity without the use of specific su…
Among marine toxins, tetrodotoxin (TTX) and paralytic shellfish poisons (PSPs) are known as notorious neurotoxins that induce serious food poisoning incidents in the Southeast Asia region. The aim of this study was to investigate whether TTX and PSP toxins are important issues of seafood safety. Paralytic toxicity was observed in mice exposed to 34 specimens from five species of gastropods usin…
Livestock units are known as one of the most influential sectors in the environment pollution. Therefore, the aim of this study was to investigate the environmental impacts of milk production in Guilan province of Iran through Life Cycle Assessment (LCA) methodology. The primary data were collected from 45 units of milk production through a field survey with the help of a structured questionnai…
In countries like Argentina, whose economy depends heavily on crop production, the estimation of harvests is an elementary requirement. Besides providing objectivity, the use of remote sensing allows estimating yield in advance. Since the time of maximum leaf area in wheat corresponds with the critical period of the crop, a good relationship is expected between the Normalized Difference Vegetat…
Changes of Land Use and Land Cover (LULC) affect atmospheric, climatic, and biological spheres of the earth. Accurate LULC map offers detail information for resources management and intergovernmental cooperation to debate global warming and biodiversity reduction. This paper examined effects of pansharpening and atmospheric correction on LULC classification. Object-Based Support Vector Machine …
Task allocation is a fundamental problem in multi-robot systems where heterogeneous robots cooperate to perform a complex mission. A general requirement in a task allocation algorithm is to find an optimal set of robots to execute a certain task. This paper presents the work that harnesses an area decomposition algorithm, and a space-based middleware to facilitate task allocation process in un…
Besides water, tea is one of the most popular beverages around the world. The chemical ingredients and biological activities of tea have beensummarized recently. The current review summarizes tea aroma compounds and their formation in green, black, and oolong tea. The flavor of teacan be divided into two categories: taste (non-volatile compounds) and aroma (volatile compounds). All of these aro…
2014AbstractThe energy substances (mainly carbohydrates and fats) are the basis and guarantee of life activity, especially the oxidative phosphorylation forenergy supply. However, excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity, hyperlipidemia,diabetes, and cancers. A large amount of studies demonstrate that G protein-coupled receptors (G…
In this paper, we utilized dimethylhydrazine (DMH)-induced colorectal cancer (CC) model rats to explore the effects of casein glycomacropeptide (CGMP) on colorectal cancer. Rats with CC were orally administrated with 10, 50, or 100 mg/kg bw d CGMP, or the same volume of phosphatebuffered saline for 15 weeks. The total numbers of aberrant crypt foci (ACF) and crypts per focus in colon were score…
Idli is a popular Indian breakfast dish consumed by many people all over the world, made from white rice (Oryza sativum) (75%–80%) and black gram (Phaseolus mungo) (20%–25%). Idli’s wide consumption makes it ideal as a model for studying acceptability of a food reformulated with whole grains. The objective was to compare acceptability regarding texture, color and sensory properties when w…
It has long been established that an adverse maternal condition impacts on the developing fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later life. However, the underlying mechanisms that are initiated during development and contribute to the disease predisposition are understudied. Recently, epigenetic reprogramming in early life has emerged as a promis…
Rattan tea, made from the leaves of Ampelopsis grossedentata, may potentially perform multiple pharmacological roles, including anti-bacterial,anti-cancer, antioxidant, hepatoprotective and anti-hypertension functions. These beneficial functions of Rattan tea are strongly associated with the bioactivity of ampelopsin, a major flavonoid compound in Rattan tea. In this review, we summarize curren…
A community of thermophiles within Tanjung Sakti Hot Spring (South Sumatera) have been cultivated and identified based on 16S ribosomal RNA gene sequence. The hot spring has temperature 80 Ce91 C and pH 7e8. We used a simple method for culturing the microbes, by enriching the spring water with nutrient broth media. Phylogenetic analysis showed that the method could recover microbes, which clu…
Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment. Dietary fibers are considered to reduce the risk of colon cancer as they are converted to short chain fatty acids by the presence of anaerobic bacteria in the intestine, but imbalanced diet and high fat consumption may promote tumor formation at different sites, including the large bow…
Corn peptides (CPs) are reported to have many biological functions, such as facilitating alcohol metabolism, antioxidation, antitumor, antihypertension, and hepatoprotection. To develop a method for quality control, the high-performance liquid chromatography (HPLC) system was applied. Twenty-eight common peaks were found in all the CPs of corn samples from Enshi, China, based on which, a finger…
Teaghrelins are unique acylated flavonoid tetraglycosides found in Chin-shin oolong tea,and have been demonstrated to be promising oral ghrelin analogues. The biosynthetic pathway of teaghrelins from quercetin-3-O-rutinoside (rutin) or kaempferol-3-O-rutinoside (nicotiflorin) was proposed to comprise three enzymatic steps according to the identification of putative intermediates in Chin-shin o…
With the objective of reducing analysis time and maintaining good efficiency, there has been substantial focus on high-speed chromatographic separations and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) is a preeminent analytical tool for rapid biomedical analysis. In this study a simple, rapid, sensitive, and specific ultra-performance liquid chromatography-MS/…
Diabetes is a condition in which there is an elevation of blood glucose. Insulin, which is produced by the pancreas, is an important hormone needed by the body because it enables glucose to be transported into cells. Under the diabetic condition, the cells may not respond properly to insulin or the body does not produce a sufficient amount of insulin, or both. This situation will cause glucose …
Tardive dyskinesia (TD) is one of the serious side effects of long-term antipsychotic treatment. Chronic treatment with neuroleptic leads to the development of abnormal oral movements called vacuous chewing movements (VCMs). The oxidative stress hypothesis of TD is one of the possible pathophysiologic models for TD. Preclinical and clinical studies of this hypothesis indicate that neurotoxic fr…
A simple, selective, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of rabeprazole (RP), pantoprazole (PP), and itopride (IP) has been developed. The compounds were well separated on a Phenomenex C18 (Luna) column (250 mm 4.6 mm, dp ¼ 5 mm) with C18 guard column (4 mm 3 mm 5 mm) with a mobile phase consisting of b…
In the presence of Britton-Robinson buffer solution (pH ¼ 9.5) and surfactant of Tween-80,fluorescence intensity of calcein was quenched by Pd2þ. However, the fluorescence intensity can be enhanced after adding a certain concentration of L-arginine, and the rate of the enhancement showed a good liner relationship with the added amount of L-arginine. We then established a fluorescence spectro…
The oxidation and reduction behavior of cefdinir (CEF) was studied by experimental methods and computational calculations at B3LYP/6-31þG (d)//AM1. Voltammetric studies were carried out based on two irreversible reduction peaks at approximately 0.5 and 1.2 V on a hanging mercury drop electrode (HMDE) and on one irreversible oxidation peak at approximately 1.0 V on a glassy carbon electrode …
A study of the binding of niclosamide (NC) to serum proteins such as human serum albumin, hemoglobin, and globulin was carried out using fluorescence and UV-visible spectroscopy. Interactions between NC and these proteins were estimated by Stern eVolmer and van’t Hoff equations. The binding constants and the thermodynamic parameters, DH, DS, and DG at different temperatures were also determin…
The taste quality of oolong tea generated from leaves of Camellia sinensis L. cultivated in the same mountain area is positively correlated to the cultivation altitude, partly due to the inverse correlation with the astringency of the tea infusion. The astringency of oolong tea mostly results from the presence of polyphenolic compounds, mainly catechins and their derivatives. Four catechins, (-…
The present study reports on the construction of a research instrument developed to examine preschool teachers’ beliefs and practices in relation to emergent literacy. A 130-item survey (Preschool Literacy Survey, PLS) was completed by a total of 90 preschool teachers in Norway. Items were grouped into homogenous scales, and the relationship between beliefs and practices was examined using st…
This article draws attention to the walking and running of young children as a key element of their multimodal communicative practices. In addition, the article argues that the walking and running of young children can be seen as a place-making activity,acknowledging the power of young children to create meaning in their world. Drawing on ethnographic data from ongoing research with young chil…
Maternal emergent literacy practices during shared-reading interactions with 18–36-month-old toddlers were examined. The investigation of emergent literacy behaviours of both mothers and toddlers investigated included the examination of phonological awareness and written language awareness. Participants included 15 mother–toddler dyads from middle to upper socio-economic status (SES) backgr…
The past decade has seen many advances in physical-layer wireless communication theory and their implementation in wireless systems. This textbook takes a unified view of the fundamentals of wireless communication and explains the web of concepts underpinning these advances at a level accessible to an audience with a basic background in probability and digital communication. Topics covered incl…
What do the fields of astronomy, economics, finance, law, mathematics, medicine, physics, and sociology have in common? Not much in the way of subject matter, that's for sure. And not all that much in the way of methodology. What they do have in common, with each other and with many other ¯elds, is their dependence on a certain standard of rationality. In each of these ¯elds, it is assum…
This is a book about the Mechanics of Solids, Statics, the Strength of Materials, and Elasticity Theory. But that doesn’t mean a thing unless you have had a course in the Mechanics of Solids, Statics, the Strength of Materials, or Elasticity Theory. I assume you have not; let us try again: This is a book that builds upon what you were supposed to learn in your basic physics and mathematics…
Thermodynamics is a branch of physics concerned with heat and temperature and their relation to energy and work. It defines macroscopic variables, such as internal energy, entropy, and pressure, that partly describe a body of matter or radiation. It states that the behavior of these variables is subject to general constraints that are common to all materials, not to the peculiar properties of p…
In 2001, an international panel of distinguished climate scientists announced that the world was warming at a rate without precedent during at least the last two millennia, and that warming was caused by the buildup of greenhouse gases from human activity. The story of how scientists reached that conclusion—by way of unexpected twists and turns—was the story Spencer R. Weart told in The Dis…
This book presents a thorough treatment of many algorithms concerning the arithmetic of elliptic curves with remarks on computer implementation. It is in three parts. First, the author describes in detail the construction of modular elliptic curves, giving an explicit algorithm for their computation using modular symbols. Second, a collection of algorithms for the arithmetic of elliptic curves …
In this article, we suggest that just as there are barriers and challenges that are particular to Chicanas/Latinas in terms of student retention and persistence,so must the mentoring offered to these students take into account their particular social, cultural, and gendered contexts. In response, we argue for a model of mujerista mentoring, building on the work of Chicana/Latina feminist schol…
This book is written for upper-division undergraduates and new graduate students in meteorology, ocean engineering, and oceanography. Because these students have a diverse background, I have emphasized ideas and concepts more than mathematical derivations.
Newton’s First Law of Motion states that an object at rest tends to stay at rest and an object in motion tends to stay in motion and once in motion, that is when it develops momentum, it will tend to stay in motion with the same speed and in the same direction unless acted upon by an external force. First elucidated in 1687 in Philosophiae Naturalis Principia Mathematica, Newton’s first law…
This study of nearly 30,000 undergraduates at 61 four-year public and private institutions examines the influence of satisfaction on students’ persistence in college. Data were collected using the Student Satisfaction Inventory (Schreiner & Juillerat, 1994) and were analyzed by class level. The hierarchical multiple regression analyses indicated that satisfaction scores accounted for an addi…